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- B2cec49e99ba66eef190e737d8e9d9e1c NCIT_P378 "NCI" @default.
- B2cec49e99ba66eef190e737d8e9d9e1c type Axiom @default.
- B2cec49e99ba66eef190e737d8e9d9e1c annotatedProperty IAO_0000115 @default.
- B2cec49e99ba66eef190e737d8e9d9e1c annotatedSource NCIT_C74598 @default.
- B2cec49e99ba66eef190e737d8e9d9e1c annotatedTarget "The sodium salt form of a benzimidazole with selective and irreversible proton pump inhibitor activity. In the acidic compartment of parietal cells, omeprazole is protonated and converted into the active achiral sulfenamide; the active sulfenamide forms one or more covalent disulfide bonds with the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting its activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production. H+/K+ ATPase is an integral membrane protein of the gastric parietal cell." @default.