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- B2d05a8653d48ab863451bf34098e4028 source "MP:0011183" @default.
- B2d05a8653d48ab863451bf34098e4028 type Axiom @default.
- B2d05a8653d48ab863451bf34098e4028 annotatedProperty UBPROP_0000008 @default.
- B2d05a8653d48ab863451bf34098e4028 annotatedSource UBERON_0008776 @default.
- B2d05a8653d48ab863451bf34098e4028 annotatedTarget "This layer can be distinguished from the overlying epiblast in the mouse embryo as early as day 4.5, and day 7 in human). The cells of the hypoblast are not thought to contribute to the developing embryo proper, but contribute to several extraembryonic structures. In rodents, the hypoblast cells form the parietal endoderm, parietal and visceral yolk sac as well as extraembryonic membranes, such as the extraembryonic endoderm, the yolk sac and the stalk that links it to the endodermal digestive tube. In human embryos, hypoblast cells migrate and line the blastocoelic cavity of the blastocyst, forming the primary yolk sac and Heuser's membrane. Although both the murine parietal yolk sac and the human primary yolk sac are transient structures, they are not developmental equivalents. A second wave of hypoblast cells migrates to form the definitive yolk sac which displaces the primary yolk sac and is equivalent to the murine visceral yolk sac. The primary yolk sac breaks up into small vesicles that can persist at the mural (abembryonic) pole." @default.