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- B2d280a14d68eda4ed4a9ab24685e2c75 NCIT_P378 "NCI" @default.
- B2d280a14d68eda4ed4a9ab24685e2c75 type Axiom @default.
- B2d280a14d68eda4ed4a9ab24685e2c75 annotatedProperty IAO_0000115 @default.
- B2d280a14d68eda4ed4a9ab24685e2c75 annotatedSource NCIT_C135619 @default.
- B2d280a14d68eda4ed4a9ab24685e2c75 annotatedTarget "A formulation of the tartrate salt form of vinorelbine, a semisynthetic vinca alkaloid, encapsulated within liposomes, with potential antineoplastic activity. Upon intravenous administration, vinorelbine binds to tubulin within tumor cells and prevents the formation of the mitotic spindle, resulting in cell cycle arrest, induction of apoptosis and an inhibition of tumor cell growth. Compared to the administration of vinorelbine alone, the liposomal formulation improves drug penetration into tumors and decreases drug clearance, thereby increasing vinorelbine's efficacy while lowering the toxicity profile." @default.