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- B2d724d023c0fb86d2fae47d53c2db531 NCIT_P378 "NCI" @default.
- B2d724d023c0fb86d2fae47d53c2db531 type Axiom @default.
- B2d724d023c0fb86d2fae47d53c2db531 annotatedProperty IAO_0000115 @default.
- B2d724d023c0fb86d2fae47d53c2db531 annotatedSource NCIT_C406 @default.
- B2d724d023c0fb86d2fae47d53c2db531 annotatedTarget "A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)" @default.