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- B2dc1f9f0d1d6f1881e35046abb2a38e2 NCIT_P378 "NCI" @default.
- B2dc1f9f0d1d6f1881e35046abb2a38e2 type Axiom @default.
- B2dc1f9f0d1d6f1881e35046abb2a38e2 annotatedProperty IAO_0000115 @default.
- B2dc1f9f0d1d6f1881e35046abb2a38e2 annotatedSource NCIT_C71156 @default.
- B2dc1f9f0d1d6f1881e35046abb2a38e2 annotatedTarget "The magnesium salt of valproic acid (2-propylpentanoic acid) with antiepileptic and potential antineoplastic activities. Magnesium valproate dissociates in the gastrointestinal tract and is absorbed into the circulation as magnesium ions and valproic acid ions; valproic acid may inhibit histone deacetylases, inducing tumor cell differentiation, apoptosis, and growth arrest. In addition, valproic acid exerts an antiepileptic effect, likely by inhibiting enzymes that catabolize the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) catabolism and so increasing concentrations of GABA in the central nervous system (CNS). The presence of the magnesium in this agent may contribute to its anticonvulsant activity and sedative properties." @default.