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- B2e197a05b7561734e20940f3c0af61d0 NCIT_P378 "NCI" @default.
- B2e197a05b7561734e20940f3c0af61d0 type Axiom @default.
- B2e197a05b7561734e20940f3c0af61d0 annotatedProperty IAO_0000115 @default.
- B2e197a05b7561734e20940f3c0af61d0 annotatedSource NCIT_C468 @default.
- B2e197a05b7561734e20940f3c0af61d0 annotatedTarget "The maleate salt form of enalapril, a dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Enalapril also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.