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- B2e2161d6022518619b111fcbeec1f10f NCIT_P378 "NCI" @default.
- B2e2161d6022518619b111fcbeec1f10f type Axiom @default.
- B2e2161d6022518619b111fcbeec1f10f annotatedProperty IAO_0000115 @default.
- B2e2161d6022518619b111fcbeec1f10f annotatedSource NCIT_C104045 @default.
- B2e2161d6022518619b111fcbeec1f10f annotatedTarget "An orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, MK-8353 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways; thereby, preventing ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a role in tumor cell proliferation, differentiation and survival." @default.