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- B2e738b87376a749067c81668f9f8a4a0 NCIT_P378 "BIOCARTA" @default.
- B2e738b87376a749067c81668f9f8a4a0 type Axiom @default.
- B2e738b87376a749067c81668f9f8a4a0 annotatedProperty NCIT_P325 @default.
- B2e738b87376a749067c81668f9f8a4a0 annotatedSource NCIT_C39180 @default.
- B2e738b87376a749067c81668f9f8a4a0 annotatedTarget "p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the cell cycle if there is damage to DNA present. It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired. The critical role of p53 is evidenced by the fact that it is mutated in a very large fraction of tumors from nearly all sources. (This definition may be outdated - see the DesignNote.)" @default.