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- B2e847e42511418d44106c0470d7472fe NCIT_P378 "NCI" @default.
- B2e847e42511418d44106c0470d7472fe type Axiom @default.
- B2e847e42511418d44106c0470d7472fe annotatedProperty IAO_0000115 @default.
- B2e847e42511418d44106c0470d7472fe annotatedSource NCIT_C82492 @default.
- B2e847e42511418d44106c0470d7472fe annotatedTarget "An antibody-drug conjugate (ADC) consisting of the recombinant anti-epidermal growth factor receptor 2 (HER2) monoclonal antibody trastuzumab conjugated to the maytansinoid DM1 via a nonreducible thioether linkage (MCC) with potential antineoplastic activity. The trastuzumab moiety of this ADC binds to HER2 on tumor cell surfaces; upon internalization, the DM1 moiety is released and binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics and inhibiting cell division and the proliferation of cancer cells that overexpress HER2. Linkage of antibody and drug through a nonreducible linker has been reported to contribute to the improved efficacy and reduced toxicity of this ADC compared to similar ADCs constructed with reducible linkers." @default.