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- B2e8e907d3ed660555051dc4ca6fd970e NCIT_P378 "NCI" @default.
- B2e8e907d3ed660555051dc4ca6fd970e type Axiom @default.
- B2e8e907d3ed660555051dc4ca6fd970e annotatedProperty IAO_0000115 @default.
- B2e8e907d3ed660555051dc4ca6fd970e annotatedSource NCIT_C872 @default.
- B2e8e907d3ed660555051dc4ca6fd970e annotatedTarget "A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. (NCI04)" @default.