Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B2ea5c7312d940c093153430504fef42d> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B2ea5c7312d940c093153430504fef42d NCIT_P378 "NCI" @default.
- B2ea5c7312d940c093153430504fef42d type Axiom @default.
- B2ea5c7312d940c093153430504fef42d annotatedProperty IAO_0000115 @default.
- B2ea5c7312d940c093153430504fef42d annotatedSource NCIT_C98079 @default.
- B2ea5c7312d940c093153430504fef42d annotatedTarget "Nonsulfonylurea insulin secretagogues and analogues of meglitinide with antihyperglycemic activity. Meglitinide antidiabetic agents bind to the ATP-sensitive inwardly-rectifier potassium (IKATP) channels on the membranes of pancreatic beta cells in a manner similar to sulfonylureas but at a discrete contact point on the SUR1 subunit. The binding blocks the influx of positively charged potassium ions into the cells, thereby reducing potassium conductance and causing membrane depolarization. In turn, this stimulates calcium ion influx through voltage-gated calcium channels, raising intracellular calcium ion levels and leading to the release of insulin-containing granules The IKATP channels found in pancreatic islets are complexes of four IKATP 6.2 and four SUR1 subunits. Compared to sulfonylureas, meglitinides, in general, have a more rapid onset of action and a shorter half-life." @default.