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- B2ee2aebaed8c8693399d858656d43d0c NCIT_P378 "NCI" @default.
- B2ee2aebaed8c8693399d858656d43d0c type Axiom @default.
- B2ee2aebaed8c8693399d858656d43d0c annotatedProperty IAO_0000115 @default.
- B2ee2aebaed8c8693399d858656d43d0c annotatedSource NCIT_C61874 @default.
- B2ee2aebaed8c8693399d858656d43d0c annotatedTarget "A carbazole derivative and a selective serotonin receptor antagonist with antiemetic activity. Palonosetron competitively blocks the action of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors located on vagal afferents in the chemoreceptor trigger zone (CTZ), resulting in suppression of chemotherapy-induced nausea and vomiting. The CTZ is located in the area postrema on the dorsal surface of the medulla oblongata at the caudal end of the fourth ventricle and outside the blood-brain barrier (BBB)." @default.