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- B2ee464a1900c8ad6c27ab2874e9b58a3 NCIT_P378 "NCI" @default.
- B2ee464a1900c8ad6c27ab2874e9b58a3 type Axiom @default.
- B2ee464a1900c8ad6c27ab2874e9b58a3 annotatedProperty IAO_0000115 @default.
- B2ee464a1900c8ad6c27ab2874e9b58a3 annotatedSource NCIT_C101894 @default.
- B2ee464a1900c8ad6c27ab2874e9b58a3 annotatedTarget "A polybisphosphonate dextran-guanidine conjugate with potential anti-resorptive and antineoplastic activities. Alendronic acid and aminoguanidine were conjugated sequentially to oxidized dextran resulting in an average of 8 alendronate and 50 guanidine groups coupled to the dextran backbone. Upon administration, the poly-alendronate dextran-guanidine conjugate inhibits the mevalonate pathway by inhibiting farnesyl diphosphate synthase (FDPS) which leads to a reduction in protein prenylation and to the loss of downstream metabolites essential for osteoclast function. This eventually leads to the induction of apoptosis in osteoclasts. Also, by preventing osteoclast-mediated bone resorption, this agent decreases bone turnover and stabilizes the bone matrix. The guanidine moiety increases the nitrogen content and possibly the activity of the bisphosphonate and its ability to inhibit FDPS. In addition, the guanidine moiety facilitates cell internalization and may contribute to this agent's cytotoxicity." @default.