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- B2f4d639a174b72309d1076ed3ae14ef3 NCIT_P378 "NCI" @default.
- B2f4d639a174b72309d1076ed3ae14ef3 type Axiom @default.
- B2f4d639a174b72309d1076ed3ae14ef3 annotatedProperty IAO_0000115 @default.
- B2f4d639a174b72309d1076ed3ae14ef3 annotatedSource NCIT_C436 @default.
- B2f4d639a174b72309d1076ed3ae14ef3 annotatedTarget "The hydrochloride salt form of hydromorphone, the hydrogenated ketone of morphine, a semi-synthetic opioid with analgesic effects. Hydromorphone selectively binds the mu-opioid receptor which is linked through G-proteins. Binding stimulates the exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP) on the G-protein complex and interacts with and inhibits adenylate cyclase located at the inner surface of the plasma membrane. This leads to a reduction in intracellular cyclic 3',5'-adenosine monophosphate (cAMP). Further, voltage-gated potassium channels are activated, thereby causing hyperpolarization and reducing neuronal excitability. In addition, the opening of voltage-gated calcium channels is inhibited, thereby leading to an inhibition of calcium entry and a reduction in the release of various neurotransmitters, including GABA, vasopressin, somatostatin, insulin and glucagons." @default.