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- B2f71130f09f8c90c350db205fd79be14 NCIT_P378 "NCI" @default.
- B2f71130f09f8c90c350db205fd79be14 type Axiom @default.
- B2f71130f09f8c90c350db205fd79be14 annotatedProperty IAO_0000115 @default.
- B2f71130f09f8c90c350db205fd79be14 annotatedSource NCIT_C29385 @default.
- B2f71130f09f8c90c350db205fd79be14 annotatedTarget "The hydrochloride salt form of the d-isomer of synthetic diphenyl propionate derivative propoxyphene, with narcotic analgesic effect. This agent mimics the effects of the endogenous opiate dextropropoxyphene, by binding to mu receptors located throughout the central nervous system. The binding results in GTP to GDP exchanges on the mu-G-protein complex, by which effector adenylate cyclase is inactivated thereby decreasing intracellular cAMP. This, in turn, inhibits the release of various nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, noradrenaline, vasopressin, and somatostatin. In addition, dextropropoxyphene closes N-type voltage-gated calcium channels and opens calcium-dependent inwardly rectifying potassium channels. This results in hyperpolarization, thereby reducing neuronal excitability, which further decreases the perception of pain." @default.