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- B2fa3615b404b274c5c8dbb49b2b05e81 NCIT_P378 "NCI" @default.
- B2fa3615b404b274c5c8dbb49b2b05e81 type Axiom @default.
- B2fa3615b404b274c5c8dbb49b2b05e81 annotatedProperty IAO_0000115 @default.
- B2fa3615b404b274c5c8dbb49b2b05e81 annotatedSource NCIT_C148138 @default.
- B2fa3615b404b274c5c8dbb49b2b05e81 annotatedTarget "An orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor ODM-207 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression of oncogenic drivers that are important for cell proliferation and survival. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that bind to acetylated lysine residues in histones and play an important role during development and cellular growth. In tumor cells, BET proteins play a key role in the regulation of oncogene transcription and tumor cell proliferation." @default.