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- B2fcd78de8e0fe6644c75c1f3470840bc NCIT_P378 "NCI" @default.
- B2fcd78de8e0fe6644c75c1f3470840bc type Axiom @default.
- B2fcd78de8e0fe6644c75c1f3470840bc annotatedProperty IAO_0000115 @default.
- B2fcd78de8e0fe6644c75c1f3470840bc annotatedSource NCIT_C47756 @default.
- B2fcd78de8e0fe6644c75c1f3470840bc annotatedTarget "The hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (ADP)-induced platelet-fibrinogen binding by binding to the glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time." @default.