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- B30a21511f4fdecac09a8d1d8c2f1ee19 NCIT_P378 "NCI" @default.
- B30a21511f4fdecac09a8d1d8c2f1ee19 type Axiom @default.
- B30a21511f4fdecac09a8d1d8c2f1ee19 annotatedProperty IAO_0000115 @default.
- B30a21511f4fdecac09a8d1d8c2f1ee19 annotatedSource NCIT_C104009 @default.
- B30a21511f4fdecac09a8d1d8c2f1ee19 annotatedTarget "A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation." @default.