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- B30b7d82036a9254551f24239244cf938 NCIT_P378 "NCI" @default.
- B30b7d82036a9254551f24239244cf938 type Axiom @default.
- B30b7d82036a9254551f24239244cf938 annotatedProperty IAO_0000115 @default.
- B30b7d82036a9254551f24239244cf938 annotatedSource NCIT_C61904 @default.
- B30b7d82036a9254551f24239244cf938 annotatedTarget "The phosphate ester form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. As a glucocorticoid receptor agonist, prednisolone 21-phosphate binds to specific intracellular glucocorticoid receptors, and causes the ligand-receptor complex to be translocated to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as various cytokines and lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both potent mediators of inflammation. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cell populations." @default.