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- B3150cadd8a2c7112a5917d0f6a173e6c NCIT_P378 "NCI" @default.
- B3150cadd8a2c7112a5917d0f6a173e6c type Axiom @default.
- B3150cadd8a2c7112a5917d0f6a173e6c annotatedProperty IAO_0000115 @default.
- B3150cadd8a2c7112a5917d0f6a173e6c annotatedSource NCIT_C62047 @default.
- B3150cadd8a2c7112a5917d0f6a173e6c annotatedTarget "A local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system." @default.