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- B315e2af83dc88d547c24d712dee2c0a2 NCIT_P378 "NCI" @default.
- B315e2af83dc88d547c24d712dee2c0a2 type Axiom @default.
- B315e2af83dc88d547c24d712dee2c0a2 annotatedProperty IAO_0000115 @default.
- B315e2af83dc88d547c24d712dee2c0a2 annotatedSource NCIT_C21208 @default.
- B315e2af83dc88d547c24d712dee2c0a2 annotatedTarget "Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)" @default.