Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B316bb0ab0756ec970089891c57f11ab8> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B316bb0ab0756ec970089891c57f11ab8 NCIT_P378 "NCI" @default.
- B316bb0ab0756ec970089891c57f11ab8 type Axiom @default.
- B316bb0ab0756ec970089891c57f11ab8 annotatedProperty IAO_0000115 @default.
- B316bb0ab0756ec970089891c57f11ab8 annotatedSource NCIT_C68921 @default.
- B316bb0ab0756ec970089891c57f11ab8 annotatedTarget "A 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. Following intravenous administration, aldoxorubicin binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hypervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity." @default.