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- B317d3aec6ed60ca3fd4464286f988a23 NCIT_P378 "NCI" @default.
- B317d3aec6ed60ca3fd4464286f988a23 type Axiom @default.
- B317d3aec6ed60ca3fd4464286f988a23 annotatedProperty IAO_0000115 @default.
- B317d3aec6ed60ca3fd4464286f988a23 annotatedSource NCIT_C116720 @default.
- B317d3aec6ed60ca3fd4464286f988a23 annotatedTarget "An orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. Upon oral administration, DFP-11207 binds to and inhibits TS. This reduces thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA damage and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP)." @default.