Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B3188b02ee6157748f6c5653807f1436f> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B3188b02ee6157748f6c5653807f1436f NCIT_P378 "NCI" @default.
- B3188b02ee6157748f6c5653807f1436f type Axiom @default.
- B3188b02ee6157748f6c5653807f1436f annotatedProperty IAO_0000115 @default.
- B3188b02ee6157748f6c5653807f1436f annotatedSource NCIT_C2337 @default.
- B3188b02ee6157748f6c5653807f1436f annotatedTarget "The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling." @default.