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- B31a765afb72e352d419ebba0c8f2c2f5 NCIT_P378 "NCI" @default.
- B31a765afb72e352d419ebba0c8f2c2f5 type Axiom @default.
- B31a765afb72e352d419ebba0c8f2c2f5 annotatedProperty IAO_0000115 @default.
- B31a765afb72e352d419ebba0c8f2c2f5 annotatedSource NCIT_C64621 @default.
- B31a765afb72e352d419ebba0c8f2c2f5 annotatedTarget "A fully human monoclonal agonistic antibody directed against tumor necrosis factor-alpha (TNF-alpha)-related apoptosis-inducing ligand receptor-2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural ligand TRAIL, lexatumumab binds to and activates TRAIL-R2, which may trigger apoptosis in and inhibit the growth of TRAIL-R2-expressing tumor cells. TRAIL-R2, also known as death receptor 5 (DR5), is a member of the TNF receptor family and is expressed on many malignant cell types." @default.