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- B31f1f7e7545a62dfd2c84ccb6ac7268b NCIT_P378 "NCI" @default.
- B31f1f7e7545a62dfd2c84ccb6ac7268b type Axiom @default.
- B31f1f7e7545a62dfd2c84ccb6ac7268b annotatedProperty IAO_0000115 @default.
- B31f1f7e7545a62dfd2c84ccb6ac7268b annotatedSource NCIT_C71534 @default.
- B31f1f7e7545a62dfd2c84ccb6ac7268b annotatedTarget "An inhalation aerosol formulation containing budesonide and the fumarate dihydrate salt of formoterol with anti-inflammatory and bronchial smooth muscle-relaxing activities. The synthetic corticosteroid steroid budesonide binds to intracellular glucocorticosteroid receptors (GRs), exhibiting inhibitory activities against multiple cell types and mediators associated with allergic inflammation. The long-acting beta-adrenergic receptor agonist formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP); increased intracellular cAMP result in the relaxation of bronchial smooth muscle and inhibition of the cellular release of mediators of immediate hypersensitivity, especially from mast cells." @default.