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- B3249269e3a703a7097d90481d166f9be NCIT_P378 "NCI" @default.
- B3249269e3a703a7097d90481d166f9be type Axiom @default.
- B3249269e3a703a7097d90481d166f9be annotatedProperty IAO_0000115 @default.
- B3249269e3a703a7097d90481d166f9be annotatedSource NCIT_C51283 @default.
- B3249269e3a703a7097d90481d166f9be annotatedTarget "Human MDM2 wild-type allele is located within 12q14.3-q15 and is approximately 32 kb in length. This allele, which encodes E3 ubiquitin-protein ligase Mdm2 protein, plays a role in the regulation of transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53 and diminish its tumor suppressor capability." @default.