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- B326562369cb17ec945d1008afe6d0ee1 NCIT_P378 "NCI" @default.
- B326562369cb17ec945d1008afe6d0ee1 type Axiom @default.
- B326562369cb17ec945d1008afe6d0ee1 annotatedProperty IAO_0000115 @default.
- B326562369cb17ec945d1008afe6d0ee1 annotatedSource NCIT_C61895 @default.
- B326562369cb17ec945d1008afe6d0ee1 annotatedTarget "The sulfate salt form of polymyxin B, a mixture of the polypeptides polymyxins B1 and B2, both obtained from Bacillus polymyxa strains, with antimicrobial activity. Polymyxin B exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death." @default.