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- B32b2fe6b07126fc67b52ef964ca69fcc NCIT_P378 "NCI" @default.
- B32b2fe6b07126fc67b52ef964ca69fcc type Axiom @default.
- B32b2fe6b07126fc67b52ef964ca69fcc annotatedProperty IAO_0000115 @default.
- B32b2fe6b07126fc67b52ef964ca69fcc annotatedSource NCIT_C156773 @default.
- B32b2fe6b07126fc67b52ef964ca69fcc annotatedTarget "An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, the EGFR mutant-specific inhibitor D-0316 specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. Compared to some other EGFR inhibitors, D-0316 may have therapeutic benefits in tumors with T790M-mediated drug resistance. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.