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- B335c77b58440f149a06317c01a8b3e7c NCIT_P378 "NCI" @default.
- B335c77b58440f149a06317c01a8b3e7c type Axiom @default.
- B335c77b58440f149a06317c01a8b3e7c annotatedProperty IAO_0000115 @default.
- B335c77b58440f149a06317c01a8b3e7c annotatedSource NCIT_C94219 @default.
- B335c77b58440f149a06317c01a8b3e7c annotatedTarget "A tetravalent bispecific antibody directed against human CD30 and the human low affinity IgG Fc region receptor (FCGR3A; CD16A), with potential immunomodulating and antineoplastic activities. Upon administration, acimtamig binds to the CD16A expressed on natural killer (NK) cells with two of its binding sites and to CD30 on CD30-expressing tumor cells with the other two binding sites, thereby selectively cross-linking tumor and NK cells. This may result in NK cell activation, antibody-dependent cellular cytotoxicity (ADCC) and eventually tumor cell lysis. CD30, a cell surface receptor and a member of the tumor necrosis factor (TNF) receptor superfamily, is overexpressed in hematologic malignancies; CD16A is specifically expressed on the surface of NK cells." @default.