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- B3376ea3f240084bafc38c539f182cfa0 NCIT_P378 "NCI" @default.
- B3376ea3f240084bafc38c539f182cfa0 type Axiom @default.
- B3376ea3f240084bafc38c539f182cfa0 annotatedProperty IAO_0000115 @default.
- B3376ea3f240084bafc38c539f182cfa0 annotatedSource NCIT_C28820 @default.
- B3376ea3f240084bafc38c539f182cfa0 annotatedTarget "The besylate salt of amlodipine, a synthetic dihydropyridine with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump." @default.