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- B33d01595d5d1ff524bb64182cdbbccbe NCIT_P378 "NCI" @default.
- B33d01595d5d1ff524bb64182cdbbccbe type Axiom @default.
- B33d01595d5d1ff524bb64182cdbbccbe annotatedProperty IAO_0000115 @default.
- B33d01595d5d1ff524bb64182cdbbccbe annotatedSource NCIT_C47756 @default.
- B33d01595d5d1ff524bb64182cdbbccbe annotatedTarget "The hydrochloride salt form of ticlopidine, a thienopyridine derivative with anticoagulant property. Ticlopidine hydrochloride irreversibly inhibits adenosine-diphosphate (ADP)-induced platelet-fibrinogen binding by binding to the glycoprotein (GP) IIb/IIIA complex, one of the two purinergic receptors activated by ADP. Inhibition of the receptor activation causes the inhibition of adenylyl cyclase, results in decreased levels of cyclic adenosine monophosphate and thereby interferes with platelet membrane function and subsequent, platelet-platelet interaction, release of platelet granule constituents and prolongation of bleeding time." @default.