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- B33d511b11ee5cf5e073084ca790711a2 NCIT_P378 "NCI" @default.
- B33d511b11ee5cf5e073084ca790711a2 type Axiom @default.
- B33d511b11ee5cf5e073084ca790711a2 annotatedProperty IAO_0000115 @default.
- B33d511b11ee5cf5e073084ca790711a2 annotatedSource NCIT_C2223 @default.
- B33d511b11ee5cf5e073084ca790711a2 annotatedTarget "An iodine 131 labeled radioimmunoconjugate of monoclonal antibody (MOAB) TNT-1/B with radioimaging and antineoplastic properties. MOAB TNT-1/B was developed for radioimmunotherapy of solid tumors, designated as Tumor Necrosis Treatment (TNT). TNT exploits the presence of degenerating and necrotic cells within tumors by utilizing MOAbs directed against universal, intracellular nucleosomal determinants consisting of histone H1 and DNA. This MOAB was conjugated with biotin (B) molecules, which increase pharmacokinetic performance of the monoclonal antibody. Upon administration, iodine I 131 derlotuximab biotin delivers I 131 to tumor cells and results in the targeted imaging and/or destruction of cells with exposed necrotic antigens." @default.