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- B33e8a7959f25039bfe56a13b321d6fc0 NCIT_P378 "NCI" @default.
- B33e8a7959f25039bfe56a13b321d6fc0 type Axiom @default.
- B33e8a7959f25039bfe56a13b321d6fc0 annotatedProperty IAO_0000115 @default.
- B33e8a7959f25039bfe56a13b321d6fc0 annotatedSource NCIT_C152135 @default.
- B33e8a7959f25039bfe56a13b321d6fc0 annotatedTarget "The succinate form of rabacfosadine, an acyclic nucleotide phosphonate prodrug and polymerase inhibitor that can potentially be used for its antineoplastic activity in the treatment of lymphoma in dogs. Upon administration, rabacfosadine is hydrolyzed intracellularly to 9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2, 6-diaminopurine (cPrPMEDAP) and subsequently deaminated to 9-(2-phosphonylmethoxyethyl) guanine (PMEG) and phosphorylated to PMEG diphosphate (PMEGpp). PMEGpp binds to and inhibits DNA polymerases. This inhibits DNA synthesis, resulting in S phase arrest and induction of apoptosis." @default.