Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B348486e56d7f46c6a9a03c462396ffa2> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B348486e56d7f46c6a9a03c462396ffa2 NCIT_P378 "NCI" @default.
- B348486e56d7f46c6a9a03c462396ffa2 type Axiom @default.
- B348486e56d7f46c6a9a03c462396ffa2 annotatedProperty IAO_0000115 @default.
- B348486e56d7f46c6a9a03c462396ffa2 annotatedSource NCIT_C66215 @default.
- B348486e56d7f46c6a9a03c462396ffa2 annotatedTarget "The sodium salt form of mycophenolic acid (MPA), with immunosuppressing activity. In vivo, the active molecule MPA reversibly inhibits inosine monophosphate dehydrogenase (IMPDH) which is needed for guanine monophosphate synthesis and stops the proliferation of B and T lymphocytes. Relative to other cell types, lypmocytes are highly dependent on salvage and de novo synthesis of guanine nucleotides, thus making these cells prone to MPA cytotoxicity." @default.