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- B3498e30237af1c194f1d1c045662a2a7 NCIT_P378 "NCI" @default.
- B3498e30237af1c194f1d1c045662a2a7 type Axiom @default.
- B3498e30237af1c194f1d1c045662a2a7 annotatedProperty IAO_0000115 @default.
- B3498e30237af1c194f1d1c045662a2a7 annotatedSource NCIT_C96771 @default.
- B3498e30237af1c194f1d1c045662a2a7 annotatedTarget "The lactate form of amsacrine, an aminoacridine analog and topoisomerase II inhibitor, with antineoplastic activity. Although the exact relationship between DNA binding and its activity has yet to be fully elucidated, amsacrine intercalates DNA through its acridine moiety, and its nonintercalative headgroup impedes topoisomerase II activity, augmenting enzyme-mediated DNA cleavage and resulting in DNA double-strand breaks. This ultimately induces programmed cell death." @default.