Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/B35054601c1ab4396632753b23cff21d3> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- B35054601c1ab4396632753b23cff21d3 NCIT_P378 "NCI" @default.
- B35054601c1ab4396632753b23cff21d3 type Axiom @default.
- B35054601c1ab4396632753b23cff21d3 annotatedProperty IAO_0000115 @default.
- B35054601c1ab4396632753b23cff21d3 annotatedSource NCIT_C95225 @default.
- B35054601c1ab4396632753b23cff21d3 annotatedTarget "The sulfate salt of selumetinib, an orally active, small molecule with potential antineoplastic activity. Selumetinib is an ATP-independent inhibitor of mitogen-activated protein kinase kinase (MEK or MAPK/ERK kinase) 1 and 2. MEK 1 and 2 are dual specificity kinases that are essential mediators in the activation of the RAS/RAF/MEK/ERK pathway, are often upregulated in various cancer cells, and are drivers of diverse cellular responses, including proliferation. Inhibition of both MEK1 and 2 by selumetinib prevents the activation of MEK1/2 dependent effector proteins and transcription factors, thereby leading to an inhibition of cellular proliferation in various cancers." @default.