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- B350c17e65f2a6e60d994b042a3b0f8e0 NCIT_P378 "NCI" @default.
- B350c17e65f2a6e60d994b042a3b0f8e0 type Axiom @default.
- B350c17e65f2a6e60d994b042a3b0f8e0 annotatedProperty IAO_0000115 @default.
- B350c17e65f2a6e60d994b042a3b0f8e0 annotatedSource NCIT_C129712 @default.
- B350c17e65f2a6e60d994b042a3b0f8e0 annotatedTarget "A calcimimetic and calcium-sensing receptor (CaSR) agonist composed of a synthetic peptide comprised of seven D-amino acids that can be used to treat secondary hyperparathyroidism (sHPT) in hemodialysis patients with chronic kidney disease (CKD). Upon intravenous administration, etelcalcetide mimics calcium and allosterically binds to and activates the CaSR expressed by the parathyroid gland. This suppresses the synthesis and secretion of parathyroid hormone (PTH), thereby reducing PTH levels and lowering serum calcium and phosphorus levels. Elevated PTH is often observed in patients with CKD and is associated with dysregulated calcium-phosphate homeostasis." @default.