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- B350e5ae8c39c0953f423221276c9b7eb NCIT_P378 "NCI" @default.
- B350e5ae8c39c0953f423221276c9b7eb type Axiom @default.
- B350e5ae8c39c0953f423221276c9b7eb annotatedProperty IAO_0000115 @default.
- B350e5ae8c39c0953f423221276c9b7eb annotatedSource NCIT_C1037 @default.
- B350e5ae8c39c0953f423221276c9b7eb annotatedTarget "An agent derived from acetohydroxamic acid with potential antineoplastic activity. Caracemide inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase. In vivo, caracemide contributes to the formation of the neurotoxin methyl isocyanate; this effect, along with the agent's acetylcholinesterase activity, may be responsible for the severe central nervous system toxicity observed in clinical trials. (NCI04)" @default.