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- B355e910fee38bdbe6fe99f394066396e NCIT_P378 "NCI" @default.
- B355e910fee38bdbe6fe99f394066396e type Axiom @default.
- B355e910fee38bdbe6fe99f394066396e annotatedProperty IAO_0000115 @default.
- B355e910fee38bdbe6fe99f394066396e annotatedSource NCIT_C162757 @default.
- B355e910fee38bdbe6fe99f394066396e annotatedTarget "An inhalation solution composed of a fixed combination of the dipropionate salt form of the synthetic glucocorticoid beclomethasone and the fumarate salt form of the long-acting and selective sympathomimetic beta-receptor agonist formoterol, with anti-inflammatory and bronchial smooth muscle-relaxing activities. Upon pressurized inhalation of the beclomethasone/formoterol solution, beclomethasone binds to intracellular glucocorticoid receptors (GRs), exhibiting inhibitory activities against multiple cell types and mediators associated with allergic inflammation. Formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, activating intracellular adenylyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3', 5'-adenosine monophosphate (cAMP). Increased intracellular cAMP results in the relaxation of bronchial smooth muscle and inhibition of the cellular release of mediators of immediate hypersensitivity, especially from mast cells. This may improve lung function." @default.