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- B357fc20422fd2dd18432126b8001e16a NCIT_P378 "NCI" @default.
- B357fc20422fd2dd18432126b8001e16a type Axiom @default.
- B357fc20422fd2dd18432126b8001e16a annotatedProperty IAO_0000115 @default.
- B357fc20422fd2dd18432126b8001e16a annotatedSource NCIT_C61635 @default.
- B357fc20422fd2dd18432126b8001e16a annotatedTarget "A synthetic dihydropyridine and a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. This results in a dilatation of the main coronary and systemic arteries, decreased myocardial contractility, increased blood flow and oxygen delivery to the myocardial tissue, and decreased total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump." @default.