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- B3591140b9e90a8f83a174a9b01d48d8c NCIT_P378 "NCI" @default.
- B3591140b9e90a8f83a174a9b01d48d8c type Axiom @default.
- B3591140b9e90a8f83a174a9b01d48d8c annotatedProperty IAO_0000115 @default.
- B3591140b9e90a8f83a174a9b01d48d8c annotatedSource NCIT_C164227 @default.
- B3591140b9e90a8f83a174a9b01d48d8c annotatedTarget "An orally bioavailable inhibitor of the menin-mixed lineage leukemia (MLL; myeloid/lymphoid leukemia; KMT2A) fusion protein, with potential antineoplastic activity. Upon oral administration, ziftomenib prevents the interaction between the two proteins menin and MLL, and thus the formation of the menin-MLL complex. This reduces the expression of downstream target genes and results in an inhibition of the proliferation of MLL-rearranged leukemic cells. The menin-MLL complex plays a key role in the survival, growth and proliferation of certain kinds of leukemia cells." @default.