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- B35e3f39a10b17915a61790a47bdb8ca5 NCIT_P378 "NCI" @default.
- B35e3f39a10b17915a61790a47bdb8ca5 type Axiom @default.
- B35e3f39a10b17915a61790a47bdb8ca5 annotatedProperty IAO_0000115 @default.
- B35e3f39a10b17915a61790a47bdb8ca5 annotatedSource NCIT_C1851 @default.
- B35e3f39a10b17915a61790a47bdb8ca5 annotatedTarget "A dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy." @default.