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- B35fb27bcae5667aa06e6fcb22b3630ac date_retrieved "2012-09-17" @default.
- B35fb27bcae5667aa06e6fcb22b3630ac external_class "VHOG:0000048" @default.
- B35fb27bcae5667aa06e6fcb22b3630ac ontology "VHOG" @default.
- B35fb27bcae5667aa06e6fcb22b3630ac source "DOI:10.1016/j.crvi.2007.03.006 Madsen OD, Pancreas phylogeny and ontogeny in relation to a 'pancreatic stem cell'. C.R. Biologies (2007)" @default.
- B35fb27bcae5667aa06e6fcb22b3630ac source "http://bgee.unil.ch/" @default.
- B35fb27bcae5667aa06e6fcb22b3630ac type Axiom @default.
- B35fb27bcae5667aa06e6fcb22b3630ac annotatedProperty UBPROP_0000003 @default.
- B35fb27bcae5667aa06e6fcb22b3630ac annotatedSource UBERON_0000017 @default.
- B35fb27bcae5667aa06e6fcb22b3630ac annotatedTarget "In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]" @default.