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- B36ae9e7a07a89aec55738c8a646f70a0 NCIT_P378 "NCI" @default.
- B36ae9e7a07a89aec55738c8a646f70a0 type Axiom @default.
- B36ae9e7a07a89aec55738c8a646f70a0 annotatedProperty IAO_0000115 @default.
- B36ae9e7a07a89aec55738c8a646f70a0 annotatedSource NCIT_C1336 @default.
- B36ae9e7a07a89aec55738c8a646f70a0 annotatedTarget "A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)" @default.