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- B36f81fb46f4f78afa8e8610533042638 NCIT_P378 "NCI" @default.
- B36f81fb46f4f78afa8e8610533042638 type Axiom @default.
- B36f81fb46f4f78afa8e8610533042638 annotatedProperty IAO_0000115 @default.
- B36f81fb46f4f78afa8e8610533042638 annotatedSource NCIT_C116720 @default.
- B36f81fb46f4f78afa8e8610533042638 annotatedTarget "An orally available thymidylate synthase (TS) inhibitor with potential antineoplastic activity. Upon oral administration, DFP-11207 binds to and inhibits TS. This reduces thymine nucleotide synthesis, inhibits DNA synthesis and cell division, causes DNA damage and leads to tumor cell apoptosis. TS catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP)." @default.