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- B378332606a0c8542e2ccadfdfe13e264 NCIT_P378 "NCI" @default.
- B378332606a0c8542e2ccadfdfe13e264 type Axiom @default.
- B378332606a0c8542e2ccadfdfe13e264 annotatedProperty IAO_0000115 @default.
- B378332606a0c8542e2ccadfdfe13e264 annotatedSource NCIT_C180825 @default.
- B378332606a0c8542e2ccadfdfe13e264 annotatedTarget "A T-cell redirecting agent and humanized immunoglobulin (Ig) G1 bispecific antibody targeting both human kallikrein-2 (hK2; KLK2) expressed on tumor cells and the CD3 receptor complex expressed on T-cells, with potential immunomodulating and antineoplastic activities. Upon subcutaneous administration, anti-KLK2/CD3 bispecific antibody JNJ-78278343 binds to both CD3 on T-cells and KLK2 on KLK2-expressing tumor cells. The resulting cross-linkage activates and redirects T-cells to KLK2-expressing tumor cells. This results in T-cell-mediated lysis of KLK2-expressing tumor cells. KLK2 is overexpressed in certain tumors, including prostate adenocarcinoma." @default.