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- B3797e1a9750487d9029ae6160db3d58e NCIT_P378 "NCI" @default.
- B3797e1a9750487d9029ae6160db3d58e type Axiom @default.
- B3797e1a9750487d9029ae6160db3d58e annotatedProperty IAO_0000115 @default.
- B3797e1a9750487d9029ae6160db3d58e annotatedSource NCIT_C1527 @default.
- B3797e1a9750487d9029ae6160db3d58e annotatedTarget "A nonsteroidal inhibitor of estrogen synthesis with antineoplastic activity. As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent breast cancer cells. Aromatase, a cytochrome P-450 enzyme localized to the endoplasmic reticulum of the cell and found in many tissues including those of the premenopausal ovary, liver, and breast, catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis." @default.