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- B379f3e4b952cbc215a5c1bac074a9335 NCIT_P378 "NCI" @default.
- B379f3e4b952cbc215a5c1bac074a9335 type Axiom @default.
- B379f3e4b952cbc215a5c1bac074a9335 annotatedProperty IAO_0000115 @default.
- B379f3e4b952cbc215a5c1bac074a9335 annotatedSource NCIT_C102978 @default.
- B379f3e4b952cbc215a5c1bac074a9335 annotatedTarget "A cell based cancer vaccine composed of mature polarized dendritic cells (DCs) and pulsed with apoptotic autologous tumor cells that has potential immunostimulating and antineoplatic activities. Dendritic cells (DCs) were treated with interleukin-1beta, tumor necrosis factor alpha, interferon-alpha (IFN-a), IFN-gamma and polyinosinic:polycytidylic acid (p-I:C) to produce mature alpha type-1 polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). The alphaDC1 are subsequently pulsed with apoptotic autologous tumor cells. Upon administration, these DCs are able to induce a potent cytotoxic T lymphocyte (CTL) response against tumor associated antigens (TAAs), resulting in tumor cell lysis and inhibition of tumor cell growth. Apoptotic tumor cells contain an array of TAAs." @default.