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- B37c5d0a082a1f01e76fae811dd7fcdd1 NCIT_P378 "NCI" @default.
- B37c5d0a082a1f01e76fae811dd7fcdd1 type Axiom @default.
- B37c5d0a082a1f01e76fae811dd7fcdd1 annotatedProperty IAO_0000115 @default.
- B37c5d0a082a1f01e76fae811dd7fcdd1 annotatedSource NCIT_C47519 @default.
- B37c5d0a082a1f01e76fae811dd7fcdd1 annotatedTarget "The hydrochloride salt form of esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation." @default.